BIOCHEMICAL STUDIES ON PTERIDINES IN PLANTS:II. BIOGENESIS OF FOLIC ACID IN GREEN LEAVES: ENZYMATIC SYNTHESIS OF DIHYDROPTEROIC ACID FROM GUANOSINE COMPOUNDS AND MECHANISM OF ITS SYNTHETIC PATHWAY

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概要

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• 1. Cell-free extracts of Brassica pekinensis Rupr (Hakusai) catalyzed the formation of dihydropteroic acid from guanosine compounds and p-aminobenzoic acid. This reaction required ATP, Mg2+ and phosphate.2. GTP and GDP were more active in dihydropteroic acid synthesis than GMP and guanosine. When GTP was used as substrate, the synthesis was absolutely dependent on ATP and Mg2+.3. 2-Amino-4-hydroxy-6-(D-erythro-1′, 2′, 3′-trihydroxypropyl) dihydropteridine was the most active as a pteridine donor for the formation of dihydropteroic acid. This enzyme reaction needed ATP and Mg2+. The L-erythro, D-threo and L-threo isomers of 2-amino-4-hydroxy-6-(D-erythro-trihydroxypropyl) dihydropteridine, 2-amino-4-hydroxy-6-(L-arabo-1′, 2′, 3′-trihydroxy-4′-deoxybutyl) dihydropteridine, 2-amino-4-hydroxy-6-(D-arabo-1′, 2′, 3′, 4′-tetrahydroxybutyl) dihydropteridine and 2-amino-4-hydroxy-6-(D-lyxo-1′, 2′, 3′, 4′-tetrahydroxybutyl) dihydropteridine were tested in the ability of enzymatic transformation to dihydropteroic acid.4. 2-Amino-4-hydroxy-6-(D-erythro-1′, 2′, 3′-trihydroxypropyl) dihydropteridine seemed to convert to 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine without ATP and Mg2+.5. 2-Amino-4-hydroxydihydropteridine and 2, 4, 5-triamino-6-hydroxypyrimidine were not involved in the synthesis of dihydropteroic acid.6. 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphate could be converted into dihydropteroic acid only in the presence of Mg2+. The monophosphate ester was not utilized in the conversion.

• 日本ビタミン学会の論文

著者

• 満田 久輝

  Laboratory of Nutritional Chemistry, Faculty of Agriculture, Kyoto University

• 田寺 謙次郎

  Laboratory of Biochemistry and Nutritional Chemistry, Department of Agricultural Chemistry, Faculty

• 田寺 謙次郎

  Laboratory of Nutritional Chemistry, Faculty of Agriculture, Kyoto University

• 鈴木 譲

  Laboratory of Nutritional Chemistry, Faculty of Agriculture, Kyoto University

• 河合 文雄

  Laboratory of Nutritional Chemistry, Faculty of Agriculture, Kyoto University

• 満田 久輝

  Laboratory of Nutritional Chemistry, Department of Food Science and Technology, Faculty of Agriculture, Kyoto Univeristy

• 鈴木 譲

  Laboratory of Nutritional Chemistry, Faculty of Agriculture Kyoto University

• 河合 文雄

  Laboratory of Food Science and Technology, Research Institute for Production Development

• 田寺 謙次郎

  Laboratory of Biochemistry and Nutritional Chemistry

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