BIOCHEMICAL STUDIES ON PTERIDINES IN PLANTS:I. BIOGENESIS OF FOLIC ACID IN GREEN LEAVES: CONFIRMATION OF ENZYMATIC SYNTHESIS OF FOLATE COMPOUNDS BY THE ENZYME SYSTEM FROM THE SPINACH

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概要

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• 1. The cell-free extracts of soy bean seedlings contained an enzyme system which converted some pteridines, p-aminobenzoic acid and glutamic acid to the compounds active for S. faecalis R (ATCC No. 8043) in the presence of ATP and Mg2+. The pteridines used in the formation of folate-active compounds were 2-amino-4-hydroxy-6-hydroxymethyltetrahydropteridine and 2-amino-4-hydroxy-6-formylpteridine.2. The partially purified enzyme system obtained from spinach leaves catalyzed among the tested pteridines most effectively the coupling reaction of 2-amino-4-hydroxymethyldihydropteridine with p-aminobenzoic acid to yield dihydropteroic acid and with p-aminobenzoylglutamic acid to form dihydrofolic acid. This reaction was dependent upon ATP and Mg2+.3. p-Aminobenzoic acid was more effective as the substrate for dihydropteroic acid synthesis than p-aminobenzoylglutamic acid for dihydrofolic acid.4. In the coupling reaction of 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine with p-aminobenzoic acid to yield dihydropteroic acid, the dihydropteridine seemed to be firstly activated by ATP and then condensed with p-aminobenzoic acid.5. General properties of dihydropteroic acid-synthesizing enzyme system were described.

• 日本ビタミン学会の論文

著者

• 田寺 謙次郎

  Laboratory of Nutritional Chemistry, Faculty of Agriculture, Kyoto University

• 満田 久輝

  Laboratory of Nutritional Chemistry, Department of Food Science and Technology, Faculty of Agriculture, Kyoto Univeristy

• 鈴木 譲

  Laboratory of Nutritional Chemistry, Faculty of Agriculture Kyoto University

• 河合 文雄

  Laboratory of Food Science and Technology, Research Institute for Production Development

• 田寺 謙次郎

  Laboratory of Biochemistry and Nutritional Chemistry

関連論文

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