Pressure of the papillary sphincter zone and pancreatic main duct in patients with alcoholic and idiopathic chronic pancreatitis.

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Duodenoscopic measurements of pressures in the papillary sphincter zone and pancreatic main duct in 20 control subjects and 31 patients with chronic pancreatitis including 10 cases of alcoholic chronic pancreatitis and 21 cases of idiopathic chronic pancreatitis.The pancreatic main ductal pressure was significantly higher in the patients with alcoholic (55.7± 28.9mmHg) or idiopathic chronic pancreatitis (44.5±25.8mmHg) than in the controls (16.2± 8.7mmHg), but there was no significant difference between patients with alcoholic and idiopathic chronic pancreatitis. There was no significant difference between control subjects and patients with chronic pancreatitis in the peak and basal pressure of the sphincter of Oddi. Nevertheless, the basal pressure and the frequency of the papillary sphincter waves in patients with alcoholic chronic pancreatitis are higher than those in normal subjects, but there were no significant differences between patients with idiopathic pancreatitis and normal subjects.These data suggest that increased pancreatic ductal pressure in patients with alcoholic pancreatitis may be due to papillary dysfunction.