Measurement of portal blood flow in the patients with obstructive jaundice using a pulsed Doppler system.

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Using a pulsed DoPPler system, the portal blood flow was measured in 6 patients with obstnlctive jaundice caused by a malignant tumor of the pancreas or of the common bile duct. The results were as follows; 1) The Mean Portal Blood Flow (MPBF) was lower in those patients (735±285ml/min) than that in 40 normal subjects (966±344ml/min) and that in 4 patients with fulminant hepatitis (1189±288ml/min). But there was not significant difference between them.2) MPBF significantly increased reaching normal range within 3 days after percutaneous transhepatic biliary decompression (p<0.01). The level of the various gastrointestinal hormones (glucagon, insulin, secretin, gastrin) was not significantly changed. 3) There was no significant relationship between MPBF and the level of total bile acid. Dehydrocholic acid did not significantly affect the portal hemodynamics in 4 healthy volunteers. These results suggest that the low MPBF may be caused by the pressure exerted on the portal vein by the dilated intrahepatic biliary tract.
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