A case of acute alcoholic hepatitis with appearance of abundant Mallory bodies in hepatitis B virus carrier state.

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The case of a 49-year-old male HBV carrier who was a member of an HBV clustering family and died of hepatic failure during a month clinical course for acute alcoholic hapatitis is reported.<BR>Autopsy revealed diffuse sublobular hepatic necrosis including bridging necrosis, perivenular hyalinosis and pericelluar fibrosis. In addition, Mallory bodies were abundantly found in the hepatocytes, around which liver cell necrosis and neutrofil infiltration were remarkable. Orcein-dye positive hepatocytes were scattered, and HBc antigen in the nuclei was rarely found. Coexsistence of Mallory bodies and Orcein positive material was not observed in the same hepatocyte. These findings suggested that it was difficult for HBV to proliferate in the hepatocytes containing Mallory bodies impling the disturbance of the cytoskeleton system.