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Many evidences support the necessity of the compatibility at major loci of the histocompatibility complex between effector and target cells, i.e. HLA restriction, in the killing mechanism of virus infected cells.<BR>In this paper, we examined the HBs antigen specific killer T cell activity in patients with various types of hepatitis B virus infection. In this new assay system autologous lymphocytes coupled with purified HBs antigen on their cell surfaces were prepared as target cells.<BR>This killer activity was detected in 6 of 8 patients with type B-acute hepatitis in convolescent stage (75.0%) and in 3 of 8 with type B-chronic active hepatitis (37.5%), but in none of all HBs antibody positive and negative healthy controls.<BR>In this assay system HLA restriction was demonstrated for the HBs antigen specific killer T cell activity, because the activity was detected only against target cells which share major loci of the histocompatibility complex with effector cells, and OKT 8 positive T cell subset proved to be responsible for the killer activity.
社団法人日本肝臓学会の論文