Serum levels and liver tissue distribution of laminin and its degraded products in the sera of patients with various liver diseases.

概要

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The significance of serum laminin was studied in various liver diseases in relation to its tissue distribution and serum degraded products. The correlation between serum laminin levels and the degree of hepatic fibrosis was obserbed. Deposition of laminin along the sinusoid in cirrhosis was supposed to be related to "capillarization". In hepatocellular carcinoma tissue, laminin was obserbed along the vessel walls of the stroma. Molecular heterogeneity of laminin P1 antigens was shown by Western immunoblotting; 280 KD laminin P1 antigen increased in the patients with hepatocellular carcinoma and metastatic liver tumor, and 350KD antigen increased in patients with other liver diseases. It was suggested that the increase of serum laminin levels might be based on different mechanisms in both groups.