Immunological mechanism in the experimental colitis in syngeneic mice induced by klebsiella oxytoca inoculation.

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In our clinical experiences, immune response against K.O. extract was demonstrated in a patient with acute hemorrhagic colitis associated with K.O. by leukocyte migration inhibition test. To determine the immunological mechanism implicated in the pathogenesis of K.O. associated colitis in man, we compared the incidence of experimental colitis in mice treated with intraperitoneal injection of AB-penicillin and inoculation of K.O. in cecum among the various immune states. In the group of immune suppressive ICR-mice irradiated by X-ray, the incidence of induced colitis (29%) was significantly lower than that (64%) in the non-irradiated controls. In the group of normal BALB/c-mice, hyperimmune mice immunized with K.O., mice receiving whole splenic cells from K.O. immunized syngeneic mice, mice receiving T-cells from K.O. immunized syngeneic mice, and mice receiving non-T cells from K.O. immunized syngeneic mice, the incidence of induced colitis were 45%, 75%, 71%, 75% and 11%, respectively. These findings suggest that cell mediated immunity to K.O. plays an important role in the pathogenesis of acute hemorrhagic colitis associated with K.O.
財団法人日本消化器病学会の論文