若干の大環状アルカロイドの合成

概要

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Synthetic works on some macrocyclic alkaloids with which the author have been concerned are reviewed. In the section 2, syntheses of bisbenzylisoquinoline alkaloids, i. e. tetrandrine 11, isotetrandrine 8, phaeanthine 20, ο-methylthalicberine 16, and (±) -cycleanine 12, are described. In the section 3, syntheses of the lactonic alkaloids isolated from the American Lythraceae plants are outlined and the details of our synthesis of lythranidine 45, a Japanese Lythraceae alkaloid isolated from Lythrum anceps by us, are also described. The fourth section deals with synthesis of the spermidine and speimine alkaloids. They are (±) -oncinotine 101, (±) -neo-oncinotine 115, pseudo-oncinotine 117, (±) -tetrahydro-lunaridine 118, etc. In addition, the “zip” reaction exploited by Schmid et al., our new synthetic method for macrocylic dilactams, and its attempted application to the syntheses of lunarine 5 and codonocarpine 133 are also introduced.
社団法人有機合成化学協会の論文