テルペノイド(第23報)カウレンのヒドラジン-ヒドラジン塩酸塩での還元
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概要
- 論文の詳細を見る
It had been found that Wolff-Kishner reduction of ent-15-kauren-6-on-20-al, using hydrazine hydrochloride, 98.5% hydrazine, and potassium hydroxide in triethyleneglycol (Nagata's modification), gave only ent-kaurane (5), a product accompanied by the stereoselective hydrogenation of the double bond between C-15 and C-16. Various experiments using ent-16-kaurene (4) as a model compound have shown that (i) hydrogenation from 4 to 5 readily occurred by hydrazine and its hydrochloride in air, (ii) it occurred even with only hydrazine in air, but not in nitrogen, and that (iii) it occurred in the presence of hydrazine hydrochloride even in nitrogen, although the yield was rather poor. The possible mechanisms are discussed.
- 公益社団法人日本薬学会の論文
- 1972-11-25
著者
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藤田 栄一
京都大学化学研究所
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長尾 善光
京都大学化学研究所
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藤田 栄一
Osaka University Of Pharmaceutical Sciences
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長尾 善光
Institute For Chemical Research Kyoto University
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