The Antitumor and Antibacterial Activity of the Isodon Diterpenoids
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概要
- 論文の詳細を見る
Oridonin (1), lasiokaurin (2), enmein (8), and enmein-3-acetate (9) and related compounds (3 and 10,) all of which have α-methylene cyclopentanone function in their molecule, have been shown to have antitumor activity against Ehrlich ascites carcinoma inoculated into mice. These compounds have also indicated specific activity against gram-positive bacteria. On the other hand, oridonin dihydro-derivative (4), compound (5), trichokaurin (6), and dihydroenmein (11) show any activity against neither tumor nor bacteria. Thus, it is concluded that the α-methylene-cyclopentanone system must be an important active center. Biomimetic reactions of oridonin and enmein with several thiols etc. support this conclusion.
- 公益社団法人日本薬学会の論文
- 1976-09-25
著者
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黒田 浩之
Kyoto College Of Pharmacy
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金子 喜三好
Institute For Chemical Research Kyoto University
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藤田 栄一
Osaka University Of Pharmaceutical Sciences
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長尾 善光
Institute For Chemical Research Kyoto University
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中澤 昭三
Kyoto College Of Pharmacy
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