肝疾患におけるLecithin:Cholesterol Acyltransferase活性--特にHigh Density Lipoproteinコレステロ-ルとの関係

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Plasma LCAT activities were determined in patients with chronic liver diseases and in normal controls, by measurement of plasma cholesterol esterification during 2 hours' incubation with dipalmitoyl lecithin sols. In cirrhotics, plasma LCAT activities were reduced and the values were significantly correlated with the ratios of esterified cholesterol to total cholesterol (CE ratio) both in plasma and in HDL. The ratios of total cholesterol present in HDL to that in plasma were not significantly different between cirrhotics and controls. Highly significant correlation of LCAT activities to serum albumin levels, prothrombin time and ICG excretion were found in cirrhotics.<BR>These findings support that in cirrhotics, decreases in both esterified cholesterol levels and CE ratios were mainly due to a reduction of plasma LCAT activities. Futhermore this reduction of LCAT activities was supposed to be related to a decrease in functional liver mass, which was demonstrated by the reduction of ICG excretion.
社団法人日本肝臓学会の論文