Characterization of Trans Eicosapentaenoic Acid Isomers: Oxidative Stability and Anti-Inflammatory Activity
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概要
- 論文の詳細を見る
Although trans geometric isomers of unsaturated fatty acids are formed during heat treatment, little is known about the physicochemical properties and the bioactivities of trans eicosapentaenoic acid (TEPA). We examined the oxidative stability and the anti-inflammatory activity of TEPA prepared using p-toluenesulfinic acid. TEPA was more stable to oxidation induced by radical generators than eicosapentaenoic acid (EPA) in organic and in aqueous solutions, and was less suitable as a substrate for 15-lipoxygenase oxidation than was EPA. These results suggest that the trans conformation may be a more stable structure to oxidation. In addition, the release of leukotriene B4 (LTB4) from Ca-ionophore-stimulated rat peritoneal exudate cells (PEC) was not affected by treatment with TEPA, and TEPA was taken up into PEC at lower levels compared to EPA. These results suggest that dietary TEPA has different physiological effects than EPA.
- 日本油化学会の論文
著者
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NAKAMURA Kazuyuki
Department of Pediatrics, Yamagata Prefectural Nihonkai Hospital
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Arai Hirofumi
Department Of Marine Bioresources Chemistry Faculty Of Fisheries Hokkaido University
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Arai H
Tokyo Sea Life Park Tokyo Jpn
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Arai Hirofumi
Department Of Biochemistry And Biomolecular Recognition Yamaguchi University School Of Medicine
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Fukunaga Kenji
Department Of Life Science And Biotechnology Faculty Of Chemistry Materials And Bioengineering And H
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HIRATA Takashi
Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University
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Zaima Nobuhiro
Division Of Applied Biosciences Graduate School Of Agriculture Kyoto University
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SUGAWARA Tatsuya
Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University
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TAKASUGI Mikako
Department of Human Nutrition, Faculty of Human Life Science, Yamaguchi Prefectural University
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NOGUCHI Ryoko
Graduate School of Fisheries Science, Hokkaido University
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Takasugi Mikako
Department Of Applied Chemistry And Biochemistry Faculty Of Engineering Kyushu Sangyo University
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Sugawara Tatsuya
Division Of Applied Biosciences Graduate School Of Agriculture Kyoto University
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Nakamura Kazuyuki
Department Of Biochemistryyamaguchi University School Of Medicine
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Sugawara Tatsuya
Graduate School Of Agriculture Kyoto Univ.
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Hirata Takashi
Division Of Applied Biosciences Graduate School Of Agriculture Kyoto University
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Nakamura Kazuyuki
Department Of Biochemistry And Biomolecular Recognition Yamaguchi University School Of Medicine
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Zaima Nobuhiro
Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University
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FUKUNAGA Kenji
Department of Biotechnology, Faculty of Engineering, Kansai University
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