蛇床子の抗白癬菌作用成分と基原植物について

概要

論文の詳細を見る
"She chuang zi" (蛇床子) described in "Shen-nung-pen-tsao-ching" (神農本草経) has been used mainly for the treatment of the swelling of women's genitals, men's impotence, and ringworm. From a commercial sample of the drug were isolated three coumarins (osthol, imperatorin, and isopimpinellin) as antidermatophytic principles of the drug. Osthol, a major pharmacologically active substance, inhibited the growth of six dermatophytes in vitro at a concentration of 6.25-12.5 μg/ml. Imperatorin and isopimpinellin were less effective than osthol. Based on the results of comparative TLC analysis of coumarin fractions, commercial samples of "She chuang zi" may be classified into the following three types. Type I She chuang zi which contains osthol and is strongly antidermatophytic was identified as fruit of Cnidium monnieri; type II which contains columbianadin and is only weakly antidermatophytic was shown to be fruit of C. formosanum; and type III which contains no coumarins and has hair on fruit was found to be fruit of Torilis sp.
日本生薬学会の論文
1984-09-20