Scopolia parviflora根茎エキスおよびDatura meteloides根エキスにおける毒性分画の比較について

概要

論文の詳細を見る
The root extract of Datura meteloides (DM), prepared by the method described in JP VII, was compared with the rhizome extract of Scopolia parvi flora (SP) regarding alkaloid content, antispasmodic activity and acute toxicity. Although no difference was found in the yield of extract on the dry weight basis between DM roots and SP rhizomes, the total alkaloid content was higher in the former. A remarkable difference was found in the l-hyoscyamine/scopolamine ratio between the two extracts, i. e, 10/68 in DM in contrast to 65/10 in SP. Antispasmodic activity was nearly proportional to total alkaloid content in the both extracts, the specific activity (atropine=1.0) being 1.82 and 1.98 for DM and SP, respectively. The results of acute toxicity tests indicated that DM extract was much more toxic for mice as compared with SP extract. This toxicity of DM extract is mainly due to a neutral, organic solvent insoluble, but water soluble fraction; whereas the main toxic component of SP extract is present in the alkaloidal fraction. The pharmacological effects of scopoletin, contained in Scopolia rhizomes, were also discussed.
日本生薬学会の論文
1970-12-20