Scopolia属植物の生薬学的研究(III) : 各国産ロート根の生理活性について

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"Extractum Scopoliae" is regulated by Japanese Pharmacopoeia VII to be extracted from the rhizome of Scopolia japonica MAXIM. (Solanaceae). Recently, however, Scopolia rhizomes imported from Korea or Europe have been used as a substitute for the Japanese Scopolia rhizomes owing to be the lack of the latter material. These foreign materials have been practically used on the chemical test of tropane alkaloids but their pharmacological evaluation has not been reported so far. In the present study, both pharmacological and chemical studies were made on the different extracts prepared from Japanese (S. japonica), Korean (S. parviflora) and East European (S. carniolica) Scopolia rhizomes, respectively. The weight of freeze-dried extract was found to be 27〜30% of the original crude-drug of each species. But as to the alkaloid content, Japanese rhizome (0.237%) showed a lower value than both Korean (0.308%) and East European (0.312%). Antispasmodic activities of the extracts from these materials and "Extractum Scopoliae" were examined by isolated rabbit ileum in Magnus apparatus. No qualitative differences in the activities seemed to be present among the three extracts. The specific activity of each extract was measured as antiacetylcholine action on isolated guinea pig ileum in Magnus apparatus using atropine as a standard. The specific activity of the sample extract was 1.96 for Japanese, 2.0 for Korean, 1.88 for East European and 1. 60 for "Extractum Scopoliae". According to the results of alkaloid contents and specific activities, the best material for "Extractum Scopoliae" is considered to be the Korean rhizome, followed by the East European and the Japanese Scopolia rhizomes in order. A similar conclusion was obtained also from the result of acute toxicity test.
日本生薬学会の論文
1969-12-15

Scopolia属植物の生薬学的研究(III) : 各国産ロート根の生理活性について

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