白〓の成分研究(補遺1) : 和白〓のクマリン成分

概要

論文の詳細を見る
From dried root of Angelica dahurica BENTH. et HOOK. var. dahurica BENTH. et HOOK., or crude drug "Japanese Bai Zhi" (Umbelliferae; Japanese name "Wa-byakshi" (TABLE 1, Chart 1), twenty-two coumarins (I-XXII) were isolated: Isolation of 15 of those coumarins from this crude drug is reported in this paper for the first time. I-XV were identified by comparison with the authentic samples. XVI, XVIII and XIX were shown to be 5-(2-hydroxy-3-methoxy-3-methylbutoxy) psoralen, 8-(2-hydroxy-3-methoxy-3-methylbutoxy)-5-methoxypsoralen (tert-O-methylbyakangelicin) and 8-(2-acetoxy-3-hydroxy-3-methylbutoxy)-5-methoxy psoralen (sec-O-acetylbyakangelicin) respectively. Physical and spectral data suggested that XVII, XX, XXI and XXII were knidilin (=cnidilin), demethylsuberosin, 6-methoxy-7-isopentenyloxycoumarin and cedrelopsin respectively. X, XI, and XIX might be artifacts formed from byak-angelicol during the extraction with hot ethyl acetate. Byak-angelicol was not isolated in the present experiment: on silica gel the epoxy ring in byakangelicol was cleaved to form byak-angelicin.
日本生薬学会の論文
1981-06-20