各種紫根のナフトキノン誘導体に関する比較研究

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Forty-three commercial samples of Lithospermi Radix (Shikon, zicao), mostly from Japan, China, Hong Kong and Korea, were assayed for their red naphtoquinone-pigment content. Assay of pigment components and their stereochemistry was also performed. Morphologically these samples belong either to Ko-shikon (Yingzicao) which is probably the root of Lithospermum erythrorhizon or to Nan-shikon (Ruanzicao) which is the root of Arnebia euchroma growing in Sinkiang province of China. The total pigment content was found to vary widely ranging from 0.1% to 7.7% in Nan-shikon (23 samples) and from 0.5% to-3.2% in Ko-shikon (19 samples). HPLC analyses of MeOH extracts showed that all the samples of Nan-shikon tested contained the teracryl derivatives but that none of Ko-shikon extracts excepting one sample contained them. The CD measurements of the whole red pigments extracted from crude drugs with CHCl_3 showed that some of the 23 samples of Nan-shikon tested contained alkannin derivatives only and the rest contained a major quantity of alkannin derivatives(S-configuration)and minor amount of shikonin derivatives (R-configuration). In the case of the whole pigments extracted from Ko-shikon 12 samples contained a major quantity of R-type with a smaller amount of S-type, 5 sampels contained a major amount of S-type with a minor quantity of R-type, and one sample contained R-type and S-type in about the same quantity. Some of the Ko-shikon samples containing alkannin derivatives might be the root of some other boraginaceous species, such as Arnebia guttata growing in inner Mongolia. The individual pigments isolated in pure form from Ko-shikon were shown to be mixtures of enantiomers, i.e. shikonin and alkannin derivatives, in various ratios.
日本生薬学会の論文
1983-12-20

各種紫根のナフトキノン誘導体に関する比較研究

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