ISOLATION OF THE INTERMEDIATES AND RELATED METABOLITES OF SHIKONIN BIOSYNTHESIS FROM LITHOSPERMUM ERYTHRORHIZON CELL CULTURES

概要

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Compounds biogenetically related to shikonin in both the shikonin-producing and nonproducing cell suspension cultures of Lithosperumum erythrorhizon were investigated to compare their secondary metabolism. From the shikonin-producing cultures two intermediates of shikonin biosynthesis, m__--geranyl-p__--hydroxybenzoic acid and geranylhydroquinone, and two shikonin-related metabolites, shikonofuran E and a new compound named deoxyshikonofuran were isolated. On the other hand, only m__--geranyl-p__--hydroxybenzoic acid was isolated from the cultures that did not produce shikonin. This suggests that a biosynthetic step leading to geranylhydroquinone from m__--geranyl-p__--hydroxybenzoic acid through decarboxylation is repressed in these cultures.
公益社団法人日本薬学会の論文
1986-05-25