没食子酸代謝物および類似化合物の抗酸化作用

概要

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Antioxidant activities of the metabolites and the analogues of esterifid gallic acids and gallic acid were investigated in this study. Esterifid gallic acids, (-)-epicatechin gallate, (-)-epigallocatechin gallate, ethyl gallate, propyl gallate, and tannic acid, and gallic acid showed high antioxidant activities as superoxide anion radical- and alkoxyl radical-scavenging activities and iron-chelating activities. Among five metabolites of gallic acid, 3, 4-dihydroxybenzoic acid and pyrogallol showed high antioxidant activities. All of these phenolic compounds include triol or o-diol in their chemical structures. Pyrocatechol, which was an analogue of gallic acid and included o-diol structure, also exhibited high antioxidant activities. These results suggest that the antioxidant activities of gallic acid and the metabolites, such as 3, 4-dihydroxybenzoic acid and pyrogallol, were thought to contribute to the activities of esterified gallic acids in animal body.
沼津工業高等専門学校の論文
2005-01-31