四塩化炭素投与ラット体内の脂質過酸化反応と脂肪族アルデヒドの生成およびその定量

概要

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The effects of the administration of carbon tetrachloride on the contents of aliphatic aldehydes in rat plasma and liver were studied. The contents of hexanal and 4-hydroxynonenal in the plasma of carbon tetrachloride administered rats (60μl/100g body weight) were significantly higher than those of control rats. The contents of 4-hydroxynonenal in the plasma of carbon tetrachloride administered rats (300μl/lOOg body weight) were lower than those of control rats. The contents of hexanal and 4-hydroxynonenal in the liver of carbon tetrachloride administered rats tended to be higher than those of control rats at both doses. These aldehydes were thought to be formed from the degradation of the peroxides of phospholipids in liver microsome and mitochondria and, at least in part, the peroxides of triglycerides accumulated in the liver of carbon tetrachloride administered rats.
沼津工業高等専門学校の論文
1991-01-30