Salacia reticulata の2 型糖尿病モデルマウスに対する予防作用

概要

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In this study, preventive effects of water extracts prepared from the stems andleaves of Salacia reticulata on a mouse model of type 2 diabetes mellitus (DM) wereinvestigated. The administration of the extract prepared from the stems of S. reticulata at adose of 0.01% (w/v) to mice improved the increased levels of plasma glucose and plasma lipidperoxides, the increased activities of intestinal sucrase and maltase, and the decreased levelsof pancreatic and plasma insulin levels observed in mice with type 2 DM. The administrationof the extract prepared from the leaves of S. reticulata at a dose of 0.01% (w/v) to mice alsotended to improved these symptoms of type 2 DM in mice. These results indicate that theadministration of the extract of S. reticulata stems and leaves could prevent type 2 DM in miceand the effects are thought to be due to the inhibition of intestinal α-glucosidase activities andthe increase of antioxidant activities.
2013-01-31