<論文>茶カテキン類のマウス体内動態

概要

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The levels of tea catechins, (-)-epicatechin (EC) and (-)-epigallocatechin gallate (EGCG), in mouse serum, bile, liver, and kidney after the oral administration of EC and EGCG were determined. Recoveries of EC and EGCG from mouse serum, bile, and the homogenates of the liver and kidney were less than 30%. A part of EC and EGCG were conjugated with sulfate and glucuronate in mouse liver homogenate. Recoveries of EC and EGCG from bovine serum albumin were lowered according to the increase of protein contents. These results indicate that EC and EGCG would be metabolized or bind to proteins in the samples. When EC was orally administered to mice, the highest levels of EC in the serum, bile, liver, and kidney were observed at 30 min. In all of these mouse samples, EC and EGCG were detected as the free, sulfate, and glucuronide at 30 min after the administration. Total contents of EC and EGCG absorbed to mouse serum, bile, liver, and kidney were tried to calculate, and those were about 0.21% and 0.31% of their doses. Therefore, it is suggested that many biological activities of tea catechins exhibited in animal bodies would be due to not only free catechins absorbed to them but also their metabolites.
沼津工業高等専門学校の論文
1999-01-29