マウスの学習記憶能に対するタバコ煙の影響

概要

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The effects of the cigarette smoke, the mainstream smoke and the sidestream smoke, and nicotine on the spatial learning and memory of mice by using Morris water maze. The mainstream smoke exposure tended to inhibit the learning and memory in mice as for each evaluation in the time required to escape onto the hidden platform in the training trials and the total stay time (time A) and the maximum stay time spent in the correct quadrant in the probe trials (time B). When the mice were exposed to the sidestream smoke, the improvement of time A was not inhibited but those of the total stay time and the celerity of time B appearance in the probe trials tended to be inhibited. Moreover, no improvement of time B was found in those mice. The intraperitoneal injection of nicotine caused an excitation or a prostration in mice and time A was extended and no improvement of time B was found. These results indicate that the exposure to the mainstream smoke and the sidestream smoke, and the administration of nicotine tended to inhibit the spatial learning and memory of mice, though the further investigations should be carried out with a large number of mice.
2006-01-31