Adsorption of Solute from the Solutions. III. Repression of Adsorption of Cyanocobalamin on Talc by Polyvinylpyrrolidone
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概要
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The adsorption of cyanocobalamin on talc was remarkably repressed by polyvinylpyrrolidone. An investigation utilizing equilibrium dialysis revealed that the repression by PVP was caused by adsorption of PVP on talc and not by any direct interaction between PVP and cyanocobalamin. Adsorption of PVP on talc was endothermic and the value of the apparent entropy change was positive. PVP and cyanocobalamin adsorbed on talc with obedience to the Langmuir isotherm equation. But the data of adsorption of the binary mixture did not fit the Markham-Benton equations but fitted a modified equations derived with an assumption that adsorption constant for cyanocobalamin on talc varied inversely as adsorbed amount of PVP. This may indicate that approach of cyanocobalamin to surface of talc is interfered by PVP molecules owing to a kind of steric hindrance.
- 公益社団法人日本薬学会の論文
- 1969-05-25
著者
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金庭 延慶
School of pharmaceutical Sciences, Showa University
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森口 郁生
School of Pharmaceutical Sciences, Kitasato University
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森口 郁生
School Of Pharmaceutical Sciences Kitasato University
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金庭 延慶
School Of Pharmaceutical Sciences Showa University
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