An Equation for Ligand Binding to Protein over a Wide Range of Ligand Concentration
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概要
- 論文の詳細を見る
A model with three parameters is proposed for the description of ligand binding behavior to protein over a wide range of ligand concentration. The equation includes a novel parameter, α, which takes account of the increase in the binding capacity of albumin caused by the binding of ligands. The validity of the equation and the implications of the parameters were examined. The equation described well the binding of bovine serum albumin (BSA) with salicylate, 4'-hydroxyazobenzene-2-carboxylate, 2-naphthoate, and benzoates. The binding data of 2-naphthoate and benzoates were analyzed by the use of multiple regression analysis to investigate the characteristics of the parameters in the equation.
- 公益社団法人日本薬学会の論文
- 1985-09-25
著者
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森口 郁生
School of Pharmaceutical Sciences, Kitasato University
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森口 郁生
School Of Pharmaceutical Sciences Kitasato University
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松下 泰雄
School of Pharmaceutical Sciences, Kitasato University
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松下 泰雄
School Of Pharmaceutical Sciences Kitasato University
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木島 弥生
School of Pharmaceutical Sciences, Kitasato University
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