Protein Bindings. V. Binding of N^4-Acetylsulfonamides to Bovine Serum Albumin
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概要
- 論文の詳細を見る
Binding constant, K_<ac>, for 11 N^4-acetylsulfonamides with bovine serum albumin was evaluated spectrophotometrically utilizing the competion between 2-(4'-hydroxyphenylazo) benzoic acid and N^4-acetylsulfonamides at 37°and 5°, and was compared with K_f, binding constant for free sulfonamides with bovine serum albumin. Free energy and entropy changes for the binding were calculated. The correlations of log (K_<ac>/K_f) with the fraction of unchanged sulfonamides excreted in the urine after the administration, and with half-life for elimination of sulfonamides from human blood plasma were indicated to be significant.
- 公益社団法人日本薬学会の論文
- 1968-08-25
著者
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森口 郁生
School of Pharmaceutical Sciences, Kitasato University
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森口 郁生
School Of Pharmaceutical Sciences Kitasato University
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和田 栄
Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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和田 栄
Research Laboratories Chugai Pharmaceutical Co. Ltd.
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