Spectroscopic Studies on Molecular Interactions. I. Complexations between Caffeine and Benzoic Acids
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概要
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Interactions between caffeine and 21 un-and mono-substituted benzoic acids were investigated at pH 7.0 and 30°by means of an indirect method utilizing the spectral change due to the competition between congo red and benzoates in complexation with caffeine. The main molar composition of the complexes appeared to be 1 : 1,and apparent equilibrium constant and free energy change for the complex formation were evaluated. The relation between the free energy change and pK_a for benzoates suggested that direct electrostatic forces between the carboxyl group in the benzoate molecules and the nitrogen of the 7-position in the caffeine molecule played a dominant role in the complexations.
- 公益社団法人日本薬学会の論文
- 1969-07-25
著者
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金庭 延慶
School of pharmaceutical Sciences, Showa University
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森口 郁生
School of Pharmaceutical Sciences, Kitasato University
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森口 郁生
School Of Pharmaceutical Sciences Kitasato University
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金庭 延慶
School Of Pharmaceutical Sciences Showa University
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名雪 美穂子
School of Pharmaceutical Sciences, Showa University
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名雪 美穂子
School Of Pharmaceutical Sciences Showa University
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