The Effect of Particle Size on the Compaction Properties and Compaction Mechanism of Sulfadimethoxine and Sulfaphenazole

概要

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The effect of particle size on compaction properties and compaction mechanism was investigated by using sulfadimethoxine (SD) and sulfaphenazole (SP) as model drugs. The plots of log(mean compaction pressure) against the thickness of the powder bed for SD and SP showed that the compaction proceeded biphasically (primary and secondary compaction) except in the case of the larger particle size fraction (42/48 mesh) for SD, and the compaction process of SD was much more markedly affected by particle size than that of SP. Analysis based on Janssen's equation suggested that the compaction proceeded by a repetitive process of structure formation and fracture. The tensile strength of SP tablets was higher than that of SD tablets, and the change in the fractional voidage indicated that all particle size fractions of SP gave tablets having the same structure. On the other hand, for SD, the larger particle size fractions showed higher tensile strength than the smaller particle size fractions in the intial compression pressure region, and measurement of the compaction energy indicated that the binding between the particles in the larger particle fractions was more effective than that of the smaller particle size fractions in that region. These results suggested that the compaction process of SD involves particle fragmentation, while that of SP involves mainly plastic deformation.
公益社団法人日本薬学会の論文
1988-07-25