スルホンアミド-水界面におけるカチオン性界面活性剤の配向とその懸濁液の分散性

概要

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Adsorption of the cationic surfactant, hexadecyltrimethylammonium bromide, on sulfadiazine, sulfaphenazole, and sulfisomidine in aqueous solution were determined at pH 5.0 and at a constant ionic strength and temperature. The ζ-potentials of these sulfonamides and porosities of the sedimentation bed of the suspensions were also measured under the same conditions. It was found that both the adsorption isotherms and ζ-potential curves for these three sulfonamides are divided into four distinct regions and the surfactant molecules adsorbed form hemimicelles at water-solid interface in the third region for all sulfonamides. The estimation of hydrophobic energy for the adsorption of the surfactant was made by the application of Grahame's equation to each adsorption isotherm and the results indicate that the hydrophobic energy between the surface of uncharged sulfonamide and hydrocarbon chains of the surfactant is important in the same way as the cohesive energy between hydrocarbon chains of adsorbed surfactants. The flocculation-deflocculation properties of the suspension may be explained by the orientation of adsorbed surfactant molecules at the water-solid interface.
公益社団法人日本薬学会の論文
1974-12-25