A Kinetic Study of the Crystallization Process of Noncrystalline Indomethacin under Isothermal Conditions

概要

論文の詳細を見る
The crystallization process of noncrystalline indomethacin (IMC) obtained by the griding and by the fusion method was analyzed by a kinetic method. The noncrystalline samples of IMC were the α form ground for 10h at 4℃(GNCα), the γform ground for 10h at 4℃(GNCγ) and the fused solid (NC). Ten kinetic models were employed, and crystallinity was determined by X-ray diffractometry. Date obtained were used to determine the thermodynamic parameters and crystallization mechanism.Under isothermal conditions GNCα crystallized in both the α and γ forms simultaneously. The GMCγ and NC crystallized in the γ form, and the results of the Hancock-Sharp method suggested the both crystallizations ocurred by a two-dimensional phase boundary reaction; the activation energies (E) were estimated to be 24.1 and 27.2 kcal/mol. The crystallization rate of GNCγ was about 60 times faster than that of NC, and therefore NC was a very stable noncrystalline solid.These results suggest that there are several kinds of noncrystalline solids.
社団法人日本薬学会の論文
1988-10-25