Induction Period for a Decrease in Molecular Weight of Polyvinylpyrrolidone by Ball-Milling in Various Kinds of Atmosphere in the Presence of Organic and Inorganic Powders
スポンサーリンク
概要
- 論文の詳細を見る
Polyvinylpyrrolidone (PVP) was ball-milled in nitrogen in the presence of chloranil, vitamin K_3,acridine, phenothiazine, p-hydroquinone, barbituric acid, white alundum, silica sands, zinc oxide, sodium chloride, activated charcoal or talc. An induction period of 20-120 hours, at the time when molecular weight of PVP began to decrease, was observed in case of ball-milling PVP in the presence of Vitamin K_3,acridine, phenothiazine, zinc oxide or talc. The induction period was longer than 200 hours in the presence of chloranil or the granules of activated charcoal. The induction period decreased by the presence of oxygen or the small quantity of the vapor of distilled water or the aqueous solution of hydrogen peroxide in the ball-milling atmosphere. The electron spin resonance (ESR) spectra of the mixtures of PVP and the additive showed that interaction was caused between them by ball-milling. When a large induction period was observed, the intensity of the signal in the ESR spectra increased slightly at the first stage of ball-milling and remarkably by ball-milling after the lapse of the induction period. The scanning electron microscopic photographs of the ball-milled mixtures suggested that the particles of the additive filled in the pores on the surface of PVP and got into the particles of PVP gradually by ball-milling. The molecular weight and the particle size of PVP seemed to begin to decrease after the particles of the additive filled in the pore thoroughly by ball-milling, when a long induction period was observed.
- 公益社団法人日本薬学会の論文
- 1977-07-25
著者
-
金庭 延慶
School of pharmaceutical Sciences, Showa University
-
池川 昭子
School Of Pharmaceutical Sciences Showa University
-
金庭 延慶
School Of Pharmaceutical Sciences Showa University
関連論文
- The Dehydration Kinetics of Theophylline Monohydrate Powder and Tablet
- A Kinetic Study of the Crystallization Process of Noncrystalline Indomethacin under Isothermal Conditions
- Effect of Environmental Temperature on the Polymorphic Transformation of Phenylbutazone during Grinding
- Effect of Environmental Temperature on Polymorphic Solid-State Transformation of Indomethacin during Grinding
- Physicochemical Characterization of Indomethacin Polymorphs and the Transformation Kinetics in Ethanol
- Effect of Tabletting on the Degree of Crystallinity and on the Dehydration and Decomposition Points of Cephalexin Crystalline Powder
- Compression Properties of Cephalexin Powder and Physical Properties of the Tablet
- The Interaction between Water and Cephalexin in the Crystalline and Noncrystalline States
- Effects of Grinding on the Physicochemical Properties of Cephalexin Powder
- Effect of Grinding on the Degree of Crystallinity of Cephalexin Powder
- Hygroscopicity and Solubility of Noncrystalline Cephalexin
- Influence of Particle Size on Physicochemical Properties of Pharmaceutical Powders. V. On Fluidity of Sodium Borate and Boric Acid Powders. (2)
- Influence of Particle Size on Physicochemical Properties of Pharmaceutical Powders. I. On Fluidity of Sodium Borate and Boric Acid Powders. (1).
- Solubilization of Amobarbital by Mechanical Treatment in the Presence of Diluents
- A Decrease in Crystallinity of Amobarbital by Mechanical Treatment in the Presence of the Diluents
- The Effect of Crystal Hardness on Compaction Propensity
- The Effect of Particle Size on the Compaction Properties and Compaction Mechanism of Sulfadimethoxine and Sulfaphenazole
- Preparation of Phenylbutazone Polymorphs and Their Transformation in Solution
- Variation in the Molecular Weight Distribution of Polyvinylpyrrolidone by Ball-Milling
- Induction Period for a Decrease in Molecular Weight of Polyvinylpyrrolidone by Ball-Milling in Various Kinds of Atmosphere in the Presence of Organic and Inorganic Powders
- Solubilization of Water-Insoluble Organic Powders by Ball-Milling in the Presence of Polyvinylpyrrolidone
- ボーミル粉砕によるPVPの分子量低下に見られるInduction Periodの検討
- Influence of Molecular Weight of Polyethylene Glycol on Interaction between Polyethylene Glycol and Iodine
- Influence of Operational Variables on Vibro-milling of Silica Sands
- Influence of Addition of Organic and Inorganic Powders on Degradation of Polyvinylprrolidone by Ball-Milling in Air
- ボールミル粉砕によるポリビニルピロリドンの分子量低下に対する添加剤の影響
- Influence of Operational Variables on Ball-Milling of Sulfadimethoxine and White Alundum
- ボールミル粉砕によるポリビニルピロリドンの分子量低下に対するふん囲気の影響
- Influence of Physicochemical Properties on Ball-Milling of Pharmaceutical Powders
- Influence of Particle Size on Physicochemical Properties of Pharmaceutical Powders. IX. Fluidity of Binary Mixtures of Potato Starch
- 粉末薬剤の粒度とその物理化学的性質(第8報) : ホワイトアランダムの流動性
- Influence of Particle Size on Physicochemical Properties of Pharmaceutical Powders. VII. Fluidity and Packing Property of Binary Mixtures
- Influence of Particle Size on Physicochemical Properties of Pharmaceutical Powders. IV. On Packing of Pharmaceutical Powders. (2)
- Influence of Particle Size on Physicochemical Properties of Pharmaceutical Powders. II. On Packing of Sodium Borate and Boric Acid Powders.
- Dissolution of Slightly Soluble Drugs. VI. Effect of Particle Size of Sulfadimethoxine on the Oral Bioavailability
- Effect of Fasting on the Elimination of Barbital and Phenobarbital in Rabbits
- Interaction between Iodine and Polyvinylpyrrolidone or α-Pyrrolidone
- Complexation of Chlorpromazine with Adenosine and Its Phosphates
- Effect of Water on Rate of Charge-Transfer Reaction of Aniline with Chloranil
- Effect of Water on Charge-Transfer Complexations
- Solvent Effects on π-π Charge-Transfer Complexations
- Spectral Changes of Various Dyes by Bovine Serum Albumin and by Organic Solvents
- Spectroscopic Studies on Molecular Interactions. VI. Mechanism of Metachromasy of 2-(4'-Hydroxyphenylazo) benzoic Acid by Serum Albumin
- Spectroscopic Studies on Molecular Interactions. V. Charge-Transfer Property and Enzymatic Acetylation of Aniline Derivatives
- Adsorption of Solute from the Solutions. IV. Adsorption of Benzoic Acids on Graphite
- Adsorption of Solute from the Solutions. V. Adsorption Rate of Cyanocobalamin on Talc
- Spectroscopic Studies on Molecular Interactions. IV. Charge-Transfer Properties and Antibacterial Activity of Sulfonamides
- Spectroscopic Studies on Molecular Interactions. III. Improvement of the Benesi-Hildebrand Method for the Determination of Equilibrium Constants
- Spectroscopic Studies on Molecular Interactions. II. Complexation between Polyvinylpyrrolidone and Iodine
- Spectroscopic Studies on Molecular Interactions. I. Complexations between Caffeine and Benzoic Acids
- Adsorption of Solute from the Solutions. III. Repression of Adsorption of Cyanocobalamin on Talc by Polyvinylpyrrolidone
- Adsorption of Solute from the Solutions. II. Competitive Adsorption of Cyanocobalamin with Pyridoxine and Thiamine on Talc
- Influence of Ball-Milling Atmosphere on Decrease of Molecular Weight of Polyvinylpyrrolidone Powders
- Dissolution of slightly Soluble Drugs. V. Effect of Particle Size on Gastrointestinal Drug Absorption and Its Relation to Solubility
- Dissolution of slightly Soluble Drugs. IV. Effect of Particle Size of Sulfonamides on in Vitro Dissolution Rate and in Vivo Absorption Rate, and Their Relation to Solubility
- Dissolution of slightly Soluble Drugs. III. Surface Condition of Powder Particles and Their Initial Dissolution Behavior
- Dissolution of Slightly Soluble Drugs. II. Effect of Particle Size on Dissolution Behavior in Sodium Lauryl Sulfate Solutions
- Dissolution of slightly Soluble Drugs. I. Influence of Particle Size on Dissolution Behavior