A Decrease in Crystallinity of Amobarbital by Mechanical Treatment in the Presence of the Diluents

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Amobarbital was ball-milled, triturated, mortar-ground or stamp-milled in the absence or in the presence of various kinds of the diluents, and influence of the mechanical treatment on the physical and chemical state of amobarbital powders was investigated. Intensity of the signals of amobarbital in the X-ray diffraction diagram decreased by the mechanical treatment. The signal of amobarbital in the DTA thermogram was not influenced by the mechanical treatment in the absence of the diluent. But the signal branched off into more than two signals, shifted to the lower temperature, decreased in intensity and disappeared by the mechanical treatment in the presence of the diluents. These phenomena were influenced more remarkably by the kind of the diluents than by the kind of the mechanical treatment. These tendencies were remarkable in the presence of precipitated silica, carbon black, granules of activated charcoal or ethyl cellulose and for the mixtures containing small amount of amobarbital. Roughly speaking, the decrease in the melting point of amobarbital in the mechanically treated mixture was remarkable, when the intensity of the signals of amobarbital in the X-ray diffraction diagram decreased markedly. It was suggested from the infrared spectra and the electron spin resonance spectra of various kinds of the samples that the interaction was caused between amobarbital and the diluent by the mechanical treatment.
公益社団法人日本薬学会の論文
1978-09-25

A Decrease in Crystallinity of Amobarbital by Mechanical Treatment in the Presence of the Diluents

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