Solubilization of Water-Insoluble Organic Powders by Ball-Milling in the Presence of Polyvinylpyrrolidone

概要

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Phenothiazine, acridine, chloranil and vitamin K_3 were ball-milled in the presence of polyvinylpyrrolidone (PVP) and the variation of the solubility and the dissolution rate of them in distilled water was investigated. Solubility of these substances in distilled water increased remarkably by ball-milling in the presence of PVP. An increase of the solubility of phenothiazine and acridine was mainly contributed to a decrease of molecular wight of PVP by ball-milling. But an increase of the solubility of chloranil and vitamin K_3 was contributed to the interaction of them with PVP caused by ball-milling. The dissolution rate of these four substances in distilled water from the mixture with PVP increased remarkably by ball-milling. The signals of phenothiazine and acridine in the X-ray diffraction diagrams of the mixture with PVP disappeared by ball-milling, and the similar tendency was also observed in case of vitamin K_3. On the contrary, new signals were observed in the diagrams of the mixture of PVP and chloranil by ball-milling. It was considered that the four substances dispersed in the solid particles of PVP in fine particles by ball-milling, which caused an increase of the solubility and the dissolution rate of them in distilled water and the change in the crystalline structure of them.
公益社団法人日本薬学会の論文
1975-11-25