The Dehydration Kinetics of Theophylline Monohydrate Powder and Tablet
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概要
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The dehydration of theophylline monohydrate in powder and tablet forms was studied by using an infrared water-content measuring instrument. Intact theophylline powder was recrystal lized from distilled water, and ground powder was obtained by grinding in a ceramic mortar with a pestle. The samples were dehydrated as follows. The intact and ground powders were placed on a plate 8 cm in diameter. A powder bed was formed on a plate 3 cm in diameter as a model of a loosely packed tablet, and a tablet 2.0 cm in diameter was obtained by compression at 1.0 t/cm^2. Dehydration kinetic mechanisms of various dosage forms of theophylline monohydrate were clarified by using various kinds of solid-state kinetic models. The dehydrations of intact and ground powders followed two-dimensional growth of nuclei and three-dimensional growth of unclei equations, and the activation energies (E_a) were 20.1 and 23.0 kcal/mol, respectively. The dehydrations of powder bed and tablet followed two-dimensional phase boundary and three-dimensional phase boundary equations, and the E_a values were 15.4 and 11.5 kcal/mol, respectively. It seems that the dehyidration of intact power starts randomly at each particle and proceeds two-dimensionally, but that of ground crystals proceeds three-dimensionally from the cracks in particles. In the case of the powder bed the dehydration proceeds two-dimensionally from the surface particles of the powder bed into the inner particles. The dehydration of a tablet proceeds three-dimensionally from the outside of the table into its inside.
- 社団法人日本薬学会の論文
- 1988-12-25
著者
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大塚 誠
School of pharmaceutical Sciences, Showa University
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金庭 延慶
School of pharmaceutical Sciences, Showa University
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金庭 延慶
School Of Pharmaceutical Sciences Showa University
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