Protein Bindings. III. Binding of Sulfonamides to Bovine Serum Albumin
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概要
- 論文の詳細を見る
Binding constant, K, for 19 sulfonamides with bovine serum albumin was evaluated spectrophotometrically utilizing the competition between 2-(4'-hydroxyphenylazo)-benzoic acid and sulfonamides. The values of log K well correlated with degree of the decrease in in vitro bacteriostatic activities by the addition of bovine serum. A linear relationship was also observed between log K and pK_a for the sulfonamides. The relationships between log K and in vitro bacteriostatic activities against Escherichia coli 0-55 and Staphylococcus aureus 209P were expressed with parabolic curves, which indicated the optimum values of log K being 3.5-4.5 for the potent sulfonamides.
- 公益社団法人日本薬学会の論文
- 1968-04-25
著者
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森口 郁生
School of Pharmaceutical Sciences, Kitasato University
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和田 栄
Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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森口 郁生
Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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和田 栄
Research Laboratories Chugai Pharmaceutical Co. Ltd.
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西沢 孝子
Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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西沢 孝子
Research Laboratories Chugai Pharmaceutical Co. Ltd.
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