Use of van der Waals Volume in Structure-Activity Studies
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概要
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Several structure-activity data which had been analysed using molar attraction constant, partition coefficient, connectivity index, and molar refraction as a parameter for drug structure were reexamined by the use of van der Waals volume (V_W). These data included actibacterial activity of penicillins, tadpole narcosis with miscellaneous compounds, inhibition of neuraminidase by dihydroisoquinolines, fungus toxicity with miscellaneous molecules, inhibition of xanthine oxidase by phenylguanines, and tuberculostatic activity of isoniazid derivatives. In all the cases, very significant correlations were found by regression analysis. These findings supported the generality of the use of V_W to analyse and predict biological activity relating to molecular structure.
- 公益社団法人日本薬学会の論文
- 1977-05-25
著者
-
森口 郁生
School Of Pharmaceutical Sciences Kitasato University
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叶田 やよい
School Of Pharmaceutical Sciences Kitasato University
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