アニリン系化合物による魚の仮死現象(I)魚類による半数致死試験実施上の問題点

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Five kinds of aniline derivatives were chosen and subjected to LC_<50> test using both static and flow water systems. The flow water system was more appropriate than the static one for volatile compounds, because 37% of N, N-dimethyl aniline in the test solution was lost during LC_<50> test for 48 h. N-Methyl aniline, N, N-dimethyl aniline and 2,6-xylidine were found to turn fish sideways producing syncope, and the states were observed during the test for 48h. Median syncopic concentration ; SC_<50> values of aniline derivatives for 48 h were determined and compared with LC_<50> values. Large differences were observed between SC_<50> and LC_<50> values in N, N-dimethyl aniline and 2,6-xylidine. A rapid determination method of aniline derivatives in fish (killifish, gold fish and carp) using FTD-GC was developed and excretion of aniline derivatives accumulated in fish were determined. All compounds except N, N-dimethyl aniline were excreted within 4 h from fish body.
公益社団法人日本薬学会の論文
1983-10-31