希土類元素の生体影響に関する研究(第4報)4種希土類元素(Dy, Eu, Yb, Y)静脈内投与時のラット臓器内Ca, Mg及びP含量の変動

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Effects of rare earth elements (REEs) on the time courses of REE, Ca, Mg and P concentrations in the liver, kidney, spleen, lung, femur and whole blood were investigated in the male rats of Wistar strain. Four kinds of REE salts, i.e. dysprosium chloride (DyCl_3), europium chloride (EuCl_3), ytterbium chloride (YbCl_3) and yttrium chloride (YCl_3)], were administered intravenously from the caudal vein (10 mg/kg as REE). Contents of REE, Ca, Mg and P were estimated by the wet digestion-ICP-AES method as a function of time. Results were as follows : 1) Concentrations of Ca in the liver, spleen and lung increased extremely in the rat administered with YCl_3. Pattern of hepatic Ca concentration as a function of time was similar to that of hepatic Y concentration, and Ca concentration was not significantly different from the control group at 45th d after the administration. Patterns of Ca concentrations were different from Y in the spleen and lung. REEs administration did not affect significantly the concentrations of Ca, Mg and P in the liver, kidney, spleen and lung except the concentrations of Ca in the liver, spleen and lung of Y-administered rats. 2) Concentrations of Ca, Mg and P in the whole blood of REE-administered rats varied from the control group within 1 d after the administration. 3) No significant effects were observed in the femoral Ca, Mg and P concentrations. 4) Concentrations of REEs in the whole blood and liver decreased exponentially in the ranges of 15 min-1 d and 1-45 d (8 h-45 d in case of YCl_3-administered rats) respectively. The half lives of Dy, Eu, Yb and Y were calculated as 6.94,6.78,6.84 and 0.427 h for the whole blood, and 16.2,21.0,15.5 and 19.3 d for the liver, respectively.
公益社団法人日本薬学会の論文
1993-02-28

希土類元素の生体影響に関する研究(第4報)4種希土類元素(Dy, Eu, Yb, Y)静脈内投与時のラット臓器内Ca, Mg及びP含量の変動

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