Biochemical Characterization of Glycyrrhizin as an Effective Inhibitor for Hyaluronidases from Bovine Testis

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概要

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• The inhibitory effects of several anti-inflammatory agents, including glycyrrhizin (GL), on the activities of hyaluronidases (HAses) purified from bovine testes and Streptomyces were investigated in vitro. It was found that (i) GL inhibits the activity of HAse (p55) from bovine testes in a dose-dependent manner, but does not affect HAse from Streptomyces; (ii) GL was the most effective of the compounds tested on bovine testis HAse activity (50% inhibition with approx. 3 μM GL); and (iii) glycyrrhetinic acid (GA), a derivative (oGA) of GA and diglucuronic acid had no detectable effects on HAse activity at 9.0 μM. The GL-induced inhibition of HAse activity is uncompetitive for its substrates. Data are provided to support the contentions that (i) bovine testis HAse (p55) is a GL-binding protein; and (ii) GL acts as a potent inhibitor of HAse in vitro.

• 公益社団法人日本薬学会の論文
• 1997-09-15

著者

• FUJIHARA Michio

  Laboratory of Genetical Biochemistry and Signal Biology, Graduate School of Medical Sciences, Kitasa

• OHTSUKI Kenzo

  Laboratory of Genetical Biochemistry and Signal Biology, Graduate School of Medical Sciences, Kitasa

• Ohtsuki K

  Kitasato Univ. Sagamihara Jpn

• Ohtsuki Kenzo

  Laboratory Of Genetical Biochemistry And Signal Biology Graduate School Of Medical Sciences Kitasato

• SHIMOYAMA Yoshihito

  Laboratory of Genetical Biochemistry, Kitasato University School of Allied Health Sciences

• FURUYA Teisuke

  Laboratory of Genetical Biochemistry, Kitasato University School of Allied Health Sciences

• Fujihara M

  Kitasato Univ. Sagamihara Jpn

• Fujihara Michio

  Laboratory Of Genetical Biochemistry School Of Allied Health Sciences Kitasato University

• Fujihara Michio

  Laboratory Of Genetical Biochemistry And Signal Biology Graduate School Of Medical Sciences Kitasato

• 大久保 研之

  Department Of Clinical Chemistry And Laboratory Medicine Faculty Of Medicine Kyushu University

• Ohtsuki Kozo

  Department Of Food Sciences And Nutritional Health Kyoto Prefectural University

• Furuya Teisuke

  Laboratory Of Genetical Biochemistry Kitasato University School Of Allied Health Sciences

• MORISHIMA Naohiko

  Laboratory of Biochemistry, School of Nursing, Kitasato University

• MORISHIMA Naohiko

  School of Nursing, Kitasato University

• YAMAGATA Shigeharu

  Laboratory of Genetical Biochemistry, School of Allied Health Sciences, Kitasato University

• Shimoyama Y

  Kitasato Univ. Sagamihara Jpn

• Yanahira Shuichi

  Technology And Research Institute Snow Brand Milk Products Co. Ltd.

• Morishima N

  School Of Nursing Kitasato University

• Yamagata Shigeharu

  Laboratory Of Genetical Biochemistry School Of Allied Health Sciences Kitasato University

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