Temperature Dependence of the Distribution of Trityl Groups in the Tritylation of 1,2-O-Isopropylidene-α-D-glucofuranose

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概要

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• The tritylation reaction of 1,2-O-isopropylidene-α-D-glucofuranose with 2.4 molar amounts of trityl chloride in pyridine at 70℃ for 20 h gave the 5,6-di-O-trityl derivative in 50% yield as the major product, whereas the reaction at 115℃ mainly gave the 3,6-di-O-trityl derivative (26% yield) along with the 6-O-trityl derivative (48% yield). The fact that the yield of the 5,6-di-O-trityl derivative at 115℃ decreased after 1 h and was 12% at 20 h is due to the redistribution of trityl groups including detritylation assisted by pyridinium chloride. It was found that tritylation of the primary hydroxyl group at C-6 was almost completed within 10 min at 115℃.

• 公益社団法人日本薬学会の論文
• 1999-10-15

著者

• Mori Y

  Laboratory Of Biochemistry School Of Nursing Kitasato University

• MORISHIMA Naohiko

  Laboratory of Biochemistry, School of Nursing, Kitasato University

• MORI Yoko

  Laboratory of Biochemistry, School of Nursing, Kitasato University

• MORISHIMA Naohiko

  School of Nursing, Kitasato University

• Morishima N

  School Of Nursing Kitasato University

関連論文

• Temperature Dependence of the Distribution of Trityl Groups in the Tritylation of 1,2-O-Isopropylidene-α-D-glucofuranose
• Biochemical Characterization of Bovine Lactoferrin as a Glycyrrhizin-Binding Protein in Vitro
• Biochemical Characterization of Glycyrrhizin as an Effective Inhibitor for Hyaluronidases from Bovine Testis

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