実験的歯周炎における Interleukin-2 Receptors (IL-2R) 発現に関する研究

概要

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Expression of receptors for Interleukin-2 (IL-2) was believed initially to be restricted to T cells after their activation by IL-1 and antigen. Recently, however, Interleukin-2 receptors (IL-2R) were demonstrated on cultured human alveolar macrophages by using an anti-IL-2R monoclonal antibody. The purpose of this study was to clarify the relationship between IL-2 and periodontitis which was induced by the injection of LPS. We examined the capacity of rat macrophages to bind anti-IL-2R monoclonal antibodies by using immunoperoxidase labeling technique. IL-2R were observed on the surface of the peritoneal macrophages isolated after the peritoneal injection of LPS. In the periodontal tissues after the gingival injection of LPS, many IL-2R were observed, especially in the lamina propria and the muscle layer. It was suggested that IL-2 which was a bacterial antigen independent factor participated in immunological response in periodontitis.
九州歯科学会の論文
1990-04-25