歯周疾患と補体に関する研究 : ヒト歯肉中の補体活性化について

概要

論文の詳細を見る
It is said that dental plaque or bacteria consume complement in periodontal disease. Complement system plays very important part in initial lesion in periodontitis. In periodontal therapy, initial preparation plays an important role. The purpose of the present study was to examine whether or not successful periodontal treatment resulted in alternations in the level of complements, C3, C3a, and C3c in gingiva. Eleven patients with periodontitis and five with healthy periodontium were subjected to this study. The patients were divided into two groups, group I and group II. The individuals in group I did not have oral hygiene and initial preparation, and those in group II have them. Periodontally healthy ones formed group III. Seven gingivae were extracted from group I, six from group II, and five from group III. The presence and levels of C3, C3a, C3c were determined by enzyme linked immunosorbent assay. The results were as follows : 1. C3 levels were significantly elevated in group I as compared with group II (p<0.05). No significant differences were detectable in other groups. 2. C3a levels were not significantly different among all groups, although there seemed to be higher C3a in group I as compared with group II or group III. 3. C3c levels were not significantly different among all groups, although there seemed to be higher C3c in group I as compared with group II or group III.
九州歯科学会の論文
1988-12-25