ラット各種臓器組織における抗樹状細胞抗体が認識する抗原の分布

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Dendritic cells (DC) are a group of cells which are constantly expressing MHC class II antigen, that is essential to antigen presentation for initiating immune responses. DC include many types of cells which are named separately for the reason of investigative processes and distribution, such as Langerhans cells, follicular dendritic cells, interdigitating cells, lymphoid dendritic cells, interstitial cells, veiled cells, indeterminated dendritic cells and so on. Because these cells are very similar to each other, these cells are classified as a family of cells. On the other hands, some diffrences were also found among these cells, and it is not clear whether the classification is suitable or not. Previously, we made a monoclonal antibody, KO 3, against rat DC in lymph nodes, and reported that KO 3-positive cells were distributed in several tissues. In this paper, we examined the distribution of the cells reacting with KO 3, 1F119, which was the other type of antibody to DC in rat, and anti-MHC class II in rats, also studied the relation between the distribution of KO 3-positive cells in tissues and the molecular weight of KO 3-positive band in western blotting. The results were as follows : 1. MHC class II-antigen appeared at the appropriate cells reacting with KO 3 in various tissues of rats. 2. The distribution of KO 3-positive cells in tissues was very similar to that of 1F119-positive cells, with the except of brain and bone marrow. 3. KO 3-positive band, in western blotting, appeared at 3 different parts equivalent for 28, 33, and 35 kDa in molecular weight in tissue extracts. 4. There were no DC subfamilies having specific KO 3-positive band alone.
九州歯科学会の論文
1993-12-25

ラット各種臓器組織における抗樹状細胞抗体が認識する抗原の分布

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