誘導マクロファージの異物に対する付着作用について

概要

論文の詳細を見る
Mouse peritoneal macrophages were induced by lipopolysaccharide (LPS), isolated and cultured for an hour. They were fixed with glutaraldehyde. Sheep erythrocytes (SRBC) and three other RBCs (mouse, rat and dog) were sensitized with LPS (LPS-RBC) and were also fixed. Each of the RBCs was added to the macrophages and incubated for 30 minutes at 37℃. Then attachment of the RBCs to the macrophages was investigated. The results obtained were as follows : 1. SRBC attached to the induced macrophages more than to the normal ones. 2. LPS-SRBC also attached to the induced macrophages more than to the normal ones. 3. LPS-SRBC attached to the normal macrophages in the same degree as SRBC. 4. SRBC and three other RBCs attached to the macrophages in the same degree. These results suggested that LPS enhanced attachment of foreigen bodies to the macrophages in vivo. And it was supposed from these results that the macrophages did not have the specific binding to SRBC.
九州歯科学会の論文
1986-02-25