誘導マクロファージの表面リセプターに関する研究 : Fc リセプターと Ia 抗原について
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In periodontal disease, it seemes that non-specific defense-response and specific immuno-response play important roles. Peritoneal macrophages were induced by the injection of E. coli and of LPS, and were studied in their development in the non-specific response and the specific response. The activity of phagocytosis of sheep red blood cells by the macrophages and the positiveness of several IgG subclass-Fc receptors (-FcRs) and of Ia antigen on the macrophages were measured. The results were as follows : 1. The phagocytosis by the E. coli-induced macrophage was more frequent on 1st, 3rd and 7th days than that by the LPS-induced macrophage. 2. The positiveness of IgG subclass-FcRs on the E. coli-induced macrophage was higher than that on the LPS-induced macrophage. 3. The positiveness of IgG subclass-FcRs decreased in the order IgG1, IgG2b, and IgG2a in the two macrophages through 7 days. In the LPS-induced macrophage, the positiveness of IgG1-FcR was 3 to 5 fold of that of IgG2a-FcR. In the E. coli-induced macrophage, the positiveness of IgG1-FcR was 7 to 10 fold of that of IgG2a-FcR. 4. In the measurement by cytotoxic test, the positiveness of Ia antigen on the E. coli-induced macrophage was higher than that in the LPS-induced macrophage. In the two macrophages the positiveness increased from 1st to 3rd days, and decreased thereafter. 5. In the measurement by enzyme-linked immunosorbent assay, the positiveness of Ia antigen on the two macrophaes increased from 1st to 3re days, and decreased on 5th day. The positiveness on the E. coli-induced macrophage was higher than that on the LPS-induced macrophage. In short, the E. coli-induced macrophage was higher in the activity of phagocytosis and in the positiveness of IgG subclass-FcRs and of Ia antigen than the LPS-indused macrophage. It seemes that the FcR positive macrophages gradually increase in phagocytotic activity, and finally express Ia antigen. Induced macrophages by antigen-injection possibly increase in non-specific phagocytotic activity at first, and then this phagocytosis provide specific immuno-response such as Ia antigen.
- 1987-06-25
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関連論文
- 誘導マクロファージの異物に対する付着作用について
- 誘導マクロファージの表面リセプターに関する研究 : Fc リセプターと Ia 抗原について
- 誘導マクロファージの表面リセプターに関する研究 : Fc リセプターと Ia 抗原について : 主論文の要旨