内毒素の歯肉内接種時における生体反応に関する研究 : 1 報 E.coli の内毒素について

概要

論文の詳細を見る
The body response to the local inoculation of endotoxin from E. coli into the rat gingiva was examined in periodontal tissue, regional lymph nodes, spleen and peripheral blood. The results obtained were as follows : 1) In periodontal tissue, the exudative inflammantion was observed in gingiva of inoculated side. Neutrophils were mainly infiltrated for 48 hours after the antigen inoculation. Lymphocytes and plasma cells began to be observed markedly from 48 hours after the inoculation. The osteocytic osteolysis by degeneration was observed at the top of the alveolar bone of inoculated side. 2) In regional lymph nodes, the antibody product cells began to be produced after 3 hours from inoculation and reached the maximum number at 6 hours. The number of appearance decreased gradually after 6 hours. The amount of antigen examined by fluorescein antibody technique was high from 48 hours to 3 days after antigen inoculation and was especially marked in the surface of small lymphocytes around primary nodule which was formed. After 5 days, the fluorescence was observed in germinal center which was in secondary nodule. In patho-histological figure, it can be consider that the vascula enlargment and edema were caused in the lymphatic field and the lymphatic sinus, because of the infiltration of wandering cells, lymphocytes and plasma cells after 24 hours. 3) In spleen, antibody product cells were fewer than that of the lymph node. The maximum value of antibody product cells was obtained in 5 to 7 days. The amount of antigen determined by fluorescein antibody technique reached the highest value at 7 days. The fluorescene was mainly recognized in cells around the lymph follicle. In patho-histological figure, the increase of primary nodule began to appear after 48 hours and the increase of secondary nodule after 14 days. 4) The serum antibody titer against endotoxin peripheral blood increased gradually to 14 days from 6 hours after inoculation. The antibody titer, however, was 1 : 320.
九州歯科学会の論文
1978-01-31

内毒素の歯肉内接種時における生体反応に関する研究 : 1 報 E.coli の内毒素について

スポンサーリンク

概要

著者

関連論文

スポンサーリンク