酒類の防腐剤に関する研究 : (第1報)清酒用防腐剤に関する研究 : 2,4-Dihydroxybenzonic acid n-hexyl ester (RA-6) の抗火落性

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Among various derivative of dihydroxybenzoic acid, 2,4-dihydroxybenzonic acid n-hexyl ester (hereafter referred to as RA-6) was found to be a good preservative for sake.(1) The minimum inhibitory concentration (MIC) of RA-6 against Hiochi bacteria lays between 8 and 15 ppm, at which the drug was about 30 times as effective as salicylic acid (SA).(2) The antimicrobial action of RA-6 against Hiochi bacteria was vacteriostatic like that of SA.(3) The antimicrobial activity of RA-6 was affected by the inoculum size of Hiochi bacteria and the alcohol concentration of the medium, but it was not affected by the pH of the medium and also by additions of peptone and various sedimentation agents to the medium.(4) RA-6 in sake was easily adsorbed to active carbon, which enabled this drug to be removed completely from sake.(5) RA-6 was stable in sake for a long time.(6) From the results of sensory tests, it found that RA-6 did not influence the color, taste, and flavour of sake at a concentration preventing the sake from the deterioration by Hiochi bacteria.(7) LD_<50> of RA-6 in the acute toxicity test by P. O. in mice was 6.309 g/kg.From these results, RA-6 is considered to be a suitable preservative for sake with a great merit of being adsorbed completely to active cabon.
社団法人日本生物工学会の論文
1971-07-25