アスコルビン酸のEscherichia coliに対する殺菌作用の機序

概要

論文の詳細を見る
The in vitro bactericidal action of L-ascorbic acid (AsA) on bacteria in the presence of a trace level of Cu^<2+> was previously reported. This paper describes the possible mechanism of the bactericdal action of AsA on Escherichia coli. Bubbling oxygen through the reaction mixture and the addition of H_2O_2 or transition metal ions to the reaction mixture enhanced the bactericidal action of AsA. On the other hand, nitrogen bubbling and the addition of reducing agents, chelating agents, radical scavengers or catalase inhibited the bactericidal action. The results indicate that oxygen radicals are involved in the bactericidal action of AsA. The in vitro single-atrand scission in bacterial DNA by the oxygen radicals was observed. In addition, the alteration of the bacterial cell surface by the oxygen radicals was suggested. Possible mechanisms of the bactericidal action of AsA were discussed.
日本ビタミン学会の論文
1991-09-25