塩基性トリペプチド誘導体のファージ不活化作用

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The synthesis of basic tripeptide derivatives, Boc-Lys-Xxx-OEt(Xxx=Leu, Pro, Trp, Phe, Gly and Ser)was previously reported. Here we describe the inactivationg effect of the derivatives on various phages(J1,T5,T4,M2,T3,φx174,δA, MS2 and φ6). The derivatives exhibited inactivating effects on these phages. In particular, Boc-Lys-Trip-Lys-OEt exhibited inactivating effect on phages J1,T3,δA and φ6. The possible mechanism of the phage-inactivating action was investigated using Boc-Lys-Trp-Lys-OEt and phage J1. Metal cations, acidic amino acids and nucleotides inhibited the inactivation of phage. Chelating agents enhanced the inactivation. Fluorescence and circular dichroism studies showed interaction between the derivative and DNA. These results indicate that the interaction of ε-amino groups of the derivatives with the phosphate residues of phage DNA could be primarily reponsible for the inactivation of phage.
社団法人日本生物工学会の論文
1991-03-25

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